Antidepressants are prescription medications that treat depression. They work to balance some of the natural chemicals in our brains. It may take several weeks for them to help. There are several types of antidepressants. Genetic variations can play a role in how we transport and metabolize antidepressant drugs.
This report is based on a study1 which found two SNPs in the ABCB1 gene that were associated with the likelihood that a person's depression symptoms would improve after taking one of four antidepressants: amitriptyline (Elavil), paroxetine (Paxil), venlafaxine (Effexor), or citalopram (Celexa). ABCB1 encodes a protein that is involved in carrying substances across the blood-brain barrier, which protects the central nervous system from potentially dangerous substances in the rest of the body.
amitriptyline (Elavil), paroxetine (Paxil), venlafaxine (Effexor), or citalopram (Celexa)