Community

A year ago, a friend of mine paid 19.95 for the variance report and got a very detailed report explaining the risks, etc associated with the report. She did not subscribe to get the info she has.
Today, I paid the same amount for the same report but see that most of the descriptions are available through subscription only.
Did Livewello change something or am I missing something?

@@NG4757, I have two family members on the v3 chip and two on v4, and I have the APOE results for all four. For v4s, the opt-in mechanism is different from when we were given health results. I was shown links in the raw data for each that said "opt-in required," but when I clicked the links, I had results for both.

23andMe talked about no calls for this specific allele before the FDA problem:

"In order to ensure that the data we return to customers is highly accurate, we use a stringent algorithm to make genotype calls. When the algorithm cannot make a confident genotype call, it gives a no call result instead. Because the data at the two APOE markers is harder to interpret, this leads to a higher percentage of customers receiving no calls than is typical for markers used in health reports."

Here's the page about "no call" and "not genotyped," generally:

https://customercare.23andme.com/hc/en-us/articles/202907630-What-does-No-call-Not-genotyped-mean...-

"In some cases, a user will not have data at a SNP location. There are two possibilities: No call and Not genotyped.

"No call: Occasionally, a user's data may not allow us to determine ... More

@@NG4757, I have two family members on the v3 chip and two on v4, and I have the APOE results for all four. For v4s, the opt-in mechanism is different from when we were given health results. I was shown links in the raw data for each that said "opt-in required," but when I clicked the links, I had results for both.

23andMe talked about no calls for this specific allele before the FDA problem:

"In order to ensure that the data we return to customers is highly accurate, we use a stringent algorithm to make genotype calls. When the algorithm cannot make a confident genotype call, it gives a no call result instead. Because the data at the two APOE markers is harder to interpret, this leads to a higher percentage of customers receiving no calls than is typical for markers used in health reports."

Here's the page about "no call" and "not genotyped," generally:

https://customercare.23andme.com/hc/en-us/articles/202907630-What-does-No-call-Not-genotyped-mean...-

"In some cases, a user will not have data at a SNP location. There are two possibilities: No call and Not genotyped.

"No call: Occasionally, a user's data may not allow us to determine his or her genotype confidently at a particular SNP. It is possible that future review will allow us to call the genotype, but until that time, the data does not appear. In downloaded data, the entry for any uncalled SNPs displays '--' instead of a two-letter genotype.

"Not genotyped: 23andMe periodically updates its DNA analysis platform to take advantage of improvements in technology. Customers tested on different versions of the platform will not have been genotyped for variants that are not included on that specific platform. For these customers, results for these variants appear in Browse Raw Data and other features as "Not Genotyped"." Less

Interesting, the rs429358 has a no call on mine. Evidently their chips contain info they decide not to share from what I read when they recently changed and added more in 23andme-I assumed this from the message they started putting on the top of their raw data when you called it up).

Yes!
A lovely detailed health report.

prometheus.com tells this info. It is only $5 to run your raw data. It has a button to import from 23andme.

And if you are fearful of following a link from somebody on a community platform, just go to snpedia.com, and type APOE in their search window. That is the page in the link.

I'm attaching a link to SNPedia, a very useful website. The link is to a page that tells how to determine your APOE. And yes, the double 4 is the one most strongly linked to AD. http://www.snpedia.com/index.php/APOE

Which snp in APOE is heterozygous? If you have a C at rs429358, then you have one ApoE allele..

My 23andMe results included health results.
You can run your results through Promethease as well.
Hope this helps!