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Yes, the MTHFR enzyme is responsible for the formation of tetrahydromethylfolate. But there is zero proof that any combination of mutations, apart from homozygous C677>T, has any serious effect on the ability of the enzyme to do that job.

Less than one person in 4000 has a mutation-free MTHFR gene. So there's no way that any particular condition can be attributed to it.

Frank Hollis; i don't think this forum is to accuse people or to assume that you know everything about everyone else's biochemistry.
As you can see from Linda Howell's posts, i fall into that category where the magnesium was not absorbing.
i was recommended by the Integrative Medicine doctor in GA, who i THINK had a lot to do with the development of LIVEWELLO, to take the Neuromag when my levels were not getting better, nor was my brain responding.

Again, not here to argue or debate, this forum is for people who want to share and help other people.... Not to accuse them. I'm not a scientist, not a doctor, and don't judge people and i'd appreciate it if you would not target me with your intellectual stuff; I simply am sharing what i have learned and what worked for me in the Magnesium department.

Thanks again for your opinions, we are all entitled to ours. Kindness would be appreciated.
barbara

Frank Hollis,
I have no info about the blood/ brain barrirr with Mg. I do know that MTHFR intetferes with the methylation process oh folaye and B-12, without which the body does not utilize Mg.
Linda

I promise you. Every single person on the planet has Mg++ floating around in their blood, no matter what format they take it in.

Do you any proof of a particular form of Mg brig better at crossing the blood-brain barrier?

Frank Hollis Glad you have all the chemical info, thanks , but what works for one doesn't necessarily work for all of us since we are all created unique.

Barbara Lake, I don't see you on Messenger. On FB. I AM Linda Carol Moore Howell. You should be able to find me.

"it's the only Magnesium that crosses the blood brain barrier, to my knowledge."

Once it gets into the body all magnesium is going to be floating around as Mg++ ions. What form it was in originally is irrelevant. That can only affect the absorption into the body.

Linda Howell, hi, i tried all the different types of Magesiums everyone told me to try; the one that works for me is Neuromag by Designs for Health; can get on Amazon, it's the only Magnesium that crosses the blood brain barrier, to my knowledge.

It does help pain, and it helps to calm down my brain from racing as much. Also, when with the functional doc in another state, he suggested 4 epsom salts baths per week in evening. This was a stretch for me, and i'm just beginning to see how much it helps. I need to make it a good time to nurture myself, put on some soft music, maybe essential oils diffusing,

i now have a larger bathtub, but so stuck, its an effort to run the bath; put a couple cups of epsom salts in, i put in vitacost lavender Essential Oil, and some people have said to put in a litlte Mule Team Borax, because it helps to absorb into the body. 20 minutes, 4 x a week, i'm not there yet. but working on it.

Some people are afraid of the chemicals in their water, and well, who knows, right ... More

Linda Howell, hi, i tried all the different types of Magesiums everyone told me to try; the one that works for me is Neuromag by Designs for Health; can get on Amazon, it's the only Magnesium that crosses the blood brain barrier, to my knowledge.

It does help pain, and it helps to calm down my brain from racing as much. Also, when with the functional doc in another state, he suggested 4 epsom salts baths per week in evening. This was a stretch for me, and i'm just beginning to see how much it helps. I need to make it a good time to nurture myself, put on some soft music, maybe essential oils diffusing,

i now have a larger bathtub, but so stuck, its an effort to run the bath; put a couple cups of epsom salts in, i put in vitacost lavender Essential Oil, and some people have said to put in a litlte Mule Team Borax, because it helps to absorb into the body. 20 minutes, 4 x a week, i'm not there yet. but working on it.

Some people are afraid of the chemicals in their water, and well, who knows, right? So, you can get some inexpensive Powdered Vitamin C, don't waste your money on the whole foods type, i think we all got scammed with that, too.

Transdermal absorption helps with the pain, and helps us to sleep better. At least an improvement, so i really need to literally put it on a huge note in my bedroom to JUST DO IT!

The Neuromag, it's not cheap, i've bought a Now brand of Magtein (this is from a patented product formulated at MIT, whatever that is worth), and not sure it works as well as the Neuromag bc of some added things like the mag. stearate and stuff; trying not to be paranoid about this.

Do Private message me, i don't know how to find how to do that on here, if you'd like to stay in touch. I only come on here when i get a notification, as i don't understand all this stuff, can't concentrate long enough.
Blessings,
barbara

 Less

Barbara Lake, my name is Linda Howell and I posted the original question!
Like you I have spent a lot of time and money looking for answers. I tested low on Magnesium so for a year I took mega doses of Magnesium Cl only to test even lower! I then took mega doses og Magnesium Oxide for a year with the same results! Finally me Functional Medicine doc tested for MTHFR!
I have severe upper arm pains that are so bad I wake up crying at night. They are neither muscular nor bone. Once she put me on Methyl Guard Plus and topical Magnesium gel, the pains went away. If I forget the methylcobalamine or topical gel, they come roaring back.

Any one else havre that experience?

yes, i have that gene of 677 also, can't remember if its homozygous or heterozygous...and Hashimoto's....ugh

@CF3032 thanks for testimony, PTL, which protocol seems to be working for you? i already spent 10/s of thousands on naturopaths, and wrong protocols, in fact, i'm B toxic, increased the panic attacks.
I'm not sure how my thyroid changed from hypothyroid to hashimotos in 2015, tho it was the first test i had n that they did the proper testing for thyroid (check the stop the thyroid madness website, lots of free resources)
They nearly kie raising the thyroid (nature throid), and i'm learning to listen to my body and not man. A recent visit to a DO , she picked up on that i was radiation abused during fascitis inmections in my neck in the 90's with a flouroscope, and she did tests to take that into consideration, sick medical eomminity!!! so, i await the blood results, also, she did a hair test for heavy metals, no one ever did that, though i spent thousands on testing.
Will see what she comes up with. meanwhile, i'm cutting my dose from 2 grains down to 1.5 grains....

Prayers for you, i wish people would put their first names at least, feel weird trying ... More

@CF3032 thanks for testimony, PTL, which protocol seems to be working for you? i already spent 10/s of thousands on naturopaths, and wrong protocols, in fact, i'm B toxic, increased the panic attacks.
I'm not sure how my thyroid changed from hypothyroid to hashimotos in 2015, tho it was the first test i had n that they did the proper testing for thyroid (check the stop the thyroid madness website, lots of free resources)
They nearly kie raising the thyroid (nature throid), and i'm learning to listen to my body and not man. A recent visit to a DO , she picked up on that i was radiation abused during fascitis inmections in my neck in the 90's with a flouroscope, and she did tests to take that into consideration, sick medical eomminity!!! so, i await the blood results, also, she did a hair test for heavy metals, no one ever did that, though i spent thousands on testing.
Will see what she comes up with. meanwhile, i'm cutting my dose from 2 grains down to 1.5 grains....

Prayers for you, i wish people would put their first names at least, feel weird trying to write to the numbers. i'm not ashamed, so i have my name on there. The gov. knows everything about us anyway, so
Bless you, each protocol is no cookie cutte eal; bc we were all created unitquely, and tired of liteening to docs when i know the panic disoreder incrased, the insomnia, the pain, etc. plus, the neuroolgical issues, which could be still from B toxicitiy, yet 4 naturopaths kept trying to make me take it, even tho i said it was making me more shaky and panicky,.

Bless you,
barbara Less

I have the MTHFR C677T, before knowing about mutations, I had gone to an endocrinologist who put me on Thyroid meds because my TSH was off according to him, I felt awful, begged him to take me off them. Then he said I had Hashimoto's disease and would have to take meds for the rest of my life. Met a great functional medicine doctor and asked me how did the endocrinologist determined you had hashimoto disease? Did he do a blood test? No, he did not. She had me do a blood test and it revealed I did not have hashimoto disease and by the way I was being overdosed on thyroid meds. Thank God for functional medicine doctors that know what to do. I treat my MTHFR with a fabulous regime and feel amazing. All the best.

yes, have both of these....i don't get the gene stuff too much and go on overload when i open up all the tests i had done.
Used to have hypothyroid, now, 'they' are saying Hasimoto's, too many Dx's, too many protocols which didn't work....so, praying for all of us...

I have the antibodies for hashimoto's thyroiditis and hetro to the MTHFR C677T gene. I was diagnosed 15 years ago but hadn't had to take any drugs until now with my Thyroid a little low. Hope it helps answer your question.

Yes, I have hashimotos, MTHFR and am c677t unsure if homo or hetero. Have had Epstein Barr Virus, still have adrenal fatigue, tons of food sensitivities. Best thing I ever did was see a functional doctor and get an immuno lab food sensitivity test. When I took out my bad foods I stopped being symptomatic. As soon as I have the food I shouldn't I feel extremely fatigued, like I've been run over by a bus and foggy brain plus a plutherer of other symptoms. There are some great books out there and plenty you can research either through you tube. My favorite ND, is Dr Morse.

In response to the original post, I wasn't diagnosed with Hashimoto's, but antibodies were borderline and I'm hypothyroid. I am homozygous C677T. I developed a goiter in my twenties but was not treated until after menopause, at which time my blood tests were still in the normal range, although ultrasound and iodine uptake test were consistent with hypothyroidism. I was barely able to function and went from doctor to doctor, with most of the classic symptoms, before I found one who was willing to put me on Armour thyroid, which quit working for me when they reformulated it in 2009 and caused daily headaches. My doctor, being a big proponent of Armour, was reluctant to believe that was the problem but helped me find a med that did work. In researching, being so puzzled about the return of my symptoms, I found that many people had a problem with the reformulated Armour. Just as an FYI to everyone.

@TA7344, are you seeing a nutritionist by chance? I am on probably most of those things and more but not getting the results I expected and I'm wondering whether to continue. But I have stealth infections (like Lyme) and Epstein-Barr, so I don't know if that's my problem. I also have hypothyroidism, and I am not one of those people on here who can go without meds. Plus, I have problems absorbing some thyroid meds, as well as certain supplements. For those of you who said thyroid meds don't work and are still symptomatic, you need to have your adrenals checked. It's a big, big deal with thyroid disease.

Yes I do. After completing the 60 elimination diet I was still having some gluten intolerance symptoms. I stopped taking my thyroid med for 7 days. Felt much better and my symptoms were greatly reduced or gone. So I decided to start my meds again. Big mistake. All symptoms returned within 12 hours. I obviously stoped them immediately. I did find out that Most Thyroid meds have gluten in them.

I have had Hashimoto's for over 25 years and neither chromosome shows a variance in the MTHFR C677T.

Yes, 25 yrs after dx thyroid ultrasound confirmed Hashimoto's. My thyroid has shrivelled up with very minimal blood supply. I have compound hetero mthfr, ace & other genetic polymorphisms. Nobody believes how sick I feel to this day.